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現在位置华东15选5浙江风采网>實驗試劑制品>生化試劑>抑制劑>上海興默生物現貨供應 GNF-6231 CAS: 1243245-18-2
上海興默生物現貨供應 GNF-6231  CAS: 1243245-18-2
上海興默生物現貨供應 GNF-6231  CAS: 1243245-18-2
  • 上海興默生物現貨供應 GNF-6231  CAS: 1243245-18-2

华东15选5预测专家推荐号: 上海興默生物現貨供應 GNF-6231 CAS: 1243245-18-2

华东15选5浙江风采网 www.hdnka.com 產品報價:詢價

更新時間:2016/6/3 15:41:42

地:上海

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號: XM

廠商性質: 生產型,

公司名稱: 上海興默生物技術有限公司

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  上海興默生物現貨供應 GNF-6231  CAS: 1243245-18-2 

 

GNF-6231 is a potent, orally active and selective Porcupine inhibitor with IC50=0.8 nM (Wnt3a Co-culture RGA). GNF-6231 demonstrated excellent pathway inhibition and induced robust antitumor efficacy in a mouse MMTV-WNT1 xenograft tumor model. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. Wnt signaling is tightly controlled during cellular proliferation, differentiation, and embryonic morphogenesis. Aberrant activation of this pathway plays a critical role in a variety of cancers, such as cutaneous squamous cell carcinoma (SCC), breast cancer, and colorectal cancer